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Nadezhda Todorova

снимка на Nadezhda Todorova

Personal information


Institute of Biodiversity and Ecosystem Research (IBER)
Bulgarian Academy of Sciences

2, Yuri Gagarin Street
Sofia 1113, Bulgaria
Phone: 00359 28717195 (via operator); 00359 887125076

Curriculum vitae


2002: MSc in Biotechnological processes, Department of Biochemistry, Faculty of Biology, Sofia University “St. Kliment Okhridski”; Thesis: Characterization of recombinant mutants of the globular fragment of C1q B-chain component of the complement system, Supervisor: Assoc. Prof. Dr. Michaela Kojuharova.

2010: PhD in Ecology, Central Laboratory of General Ecology, Bulgarian Academy of Sciences; Thesis: Structure and biodegradive potential of bacterial communities, living in oil polluted coastal marine sediments, Supervisors: Assoc. Prof. Dr. Roumiana Mironova (Institute of Molecular Biology, BAS), Dr. Ventzislav Karamfilov (Central Laboratory of General Ecology, BAS).


2003 - 2010: Research Fellow, Central Laboratory of General Ecology, BAS, Department of Functional ecology, Marine ecology workgroup.

2010 - present: Institute of Biodiversity and Ecosystem Research, BAS.

International experience:

2005-2006: Exchange visit in Institute of Microbiology-ASCR, Prague, Czech Republic, Xenobiotic biodegradation Workgroup; Participant in 6FP project BIOTOOL: Biological procedures for diagnosing the status and predicting evolution of polluted environments.

2008: International Graduate Summer School “Coastal systems under pressure”, GKSS Forschungszentrum, Lauenburg & Buesum, Germany.

2008: PhD course “Biological sequence analysis”, Center for Biological Sequence Analysis (CBS) and Technical University, Denmark.

2011: Exchange visit in University of Vienna, Austria, Department of Environmental Microbiology; Analysis of complex microbial communities and studies on evolution, diversity and function of environmental microorganisms involved in biogeochemical cycles.

2013: Computational Molecular Evolution, Technical University, Denmark (Corsera Certificate).

2014: Qualification in a high-technology science center in Europe (Project BG051PO001-3.3.05-0001 Science and Business), University of Vienna, Austria, Department of Environmental Microbiology; Molecular techniques to characterize bacterial communities in marine sediments, populated with Zostera sp. (real-time PCR, CARD-FISH of dsrAB genes).

Research interests

Microbial ecology
Molecular techniques implementation for the assessment of ecological status (bacterial component)
Ecology and biomonitoring of model prokaryotic systems
C1q autoantibodies – existence and function in autoimmune diseases, molecular approach and modelling
Microbial communities structure - biomarker for oil marine sediment pollution
Key catabolic genes in oil-degradive bacterial pathways
Diversity and function of sulphate-reducing bacteria (SRB) in coastal sediments


Tsacheva, I., M. Radanova, N. Todorova, T. Argirova, U. Kishore. 2007. Detection of autoantibodies against the globular domain of human C1q in the sera of systemic lupus erythematosus patients. Molecular Immunology. Volume 44: 2147-2151.

Todorova, N., I. Ivanov, A. Hristov, V. Karamfilov. 2005. Application of ARDREA analysis for early warning of the effects of oil pollution in coastal marine ecosystems. Research into laboratory “microcosm” model. Ecological Engineering and Environmental Protection. Volume 3-4: 69-75.

Todorova, N., V. Iotzova, V. Karamfilov, G. Hiebaum. 2008. Effect of chronic oil pollution on the structure of bacterial communities inhabiting coastal marine sediments. Comptes Rendus de l`Academie Bulgare des Sciences. Tome 61. No 3: 357-362.

Todorova, N., G. Radeva, V. Karamfilov, G. Hiebaum. 2008. Examining diversity of bacterial communities inhabiting marine coastal sediments by 16S rDNA retrieval. Journal of Balkan Ecology. Volume 11. No 3: 309-315.

Todorova, N.H. , G. Radeva and V. Karamfilov. 2012. Microbial diversity in Zostera sp. beds in south-western Black sea region analyzed by amplified ribosomal DNA restriction enzyme analysis (ARDRA). Biotechnology & Biotechnological Equipment (Special edition), Volume 26, No 1: 5-11.

Todorova N., R. Mironova, V. Karamfilov. 2014. Comparative molecular analysis of bacterial communities inhabiting pristine and polluted with polycyclic aromatic hydrocarbons Black Sea coastal sediments. Marine Pollution Bulletin, Vol. 83: 231-240.

Kopf A., M. Bicak, R. Kottmann, J. Schnetzer, I. Kostadinov, K. Lehmann, A. Fernandez-Guerra, C. Jeanthon, [...] N. Todorova, V. Karamfilov, [...] J. A. Gilbert, N. Davies, D. Field, F. O. Gloeckner. 2015. The Ocean Sampling Day Consortium (Commentary). GigaScience. 4:27. DOI: 10.1186/s13742-015-0066-5

Caruso G., R. La Ferla, M. Azzaro, A. Zoppini, G. Marino, T. Petochi, C. Corinaldesi, M. Leonardi, R. Zaccone, S. Fonda Umani, [...] N. Todorova, V. Karamfilov, E. Rastelli, S. Capello, M. I. Acquaviva, M. Narracci, R. De Angelis, P. DelNegro, M. Latini, R. Danovaro. 2015. Microbial assemblages for environmental quality assessment: knowledge, gaps and usefulness in the European Marine Strategy Framework Directive. Critical Reviews in Microbiology. DOI: 10.3109/1040841X.2015.1087380

Woerner S., S. Zecchin, J. Dan, N. H. Todorova, A. Loy, R. Conrad, M. Pester. 2016. Gypsum amendment to rice paddy soil stimulated bacteria involved in sulfur cycling but largely preserved the phylogenetic composition of the total bacterial community. Environmental Microbiology Reports. vol 8: 413-423 DOI: 10.1111/1758-2229.12413

Rangelov, M., Todorova, N., Tsacheva, I.. In silico investigation of single-chain variable fragment (scFv) antibody, structurally similar to native C1q globular heads. Bulgarian Chemical Communications, 49, Special Issue E, Institute of Chemical Engineering - BAS, 2017, ISSN:0324-1130, 50-53.

Rangelov, M., Todorova, N., Jovtchev, G.. CellRan: new conceptual program for ecosystem analysis and modelling. Животна средина - Заштита - Зборници, COBISS.SR-ID 317216519, 2017, ISBN:978-86-83177-52-3, 385-389

Todorova, N., Stankov, A., Rangelov, M., Jovtchev, G.. Has Roundup an impact on microbial commiunities of agricultural soils?. Животна средина - Заштита - Зборници, COBISS.SR-ID 317216519, 2017, ISBN:978-86-83177-52-3, 109-114

Jovtchev, G., Gateva, S., Stankov, A., Todorova, N., Kitanova, M., Topashka-Ancheva, M.. Roundup - The best protection or the creeping danger?. 21st International Eco-Conference, 12th Eco-Conference on Environmental protection of urban and suburban settlements. Proceedings 2017, Ecological Movement of Novi Sad 21000 Novi Sad, Vojvodjanskih brigada 17/I, 2017, ISBN:978-86-83177-52-3, DOI:COBISS.SR-ID 317216519, 203-212

Todorova N., Alyomov S., Chiotoroiu B.C., Fach B., Osadchaya T., Rangelov M., Salihoglu B., Vasilev V.. Black Sea Chapter 8. In: Carr H. (Ed.) World Seas: An Environmental Evaluation, Vol I: Europe, The Americas and West Africa, 2e, 1, Elsevier, 2018, ISBN:978-0-12-8050682, DOI:, 17, 209-226

Todorov, P., Rangelov, M., Peneva, P., Todorova, N., Tchekalarova, J.. Anticonvulsant evaluation and docking analysis of novel VV-Hemorphin-5 analogues. Wiley, 2019, DOI:10.1002/ddr.21514

Todorov, P., Peneva P., Tchekalarova J., Rangelov, M., Georgieva S., Todorova N.. Synthesis, characterization and anticonvulsant activity of new series of N-modified analogues of VV-Hemorphin-5 with aminophosphonate moiety. Amino Acids, Springer, 2019, DOI: 10.1007/s00726-019-02789-0

Tchekalarova J., Angelova V., Todorova N., Andreeva-Gateva P., Rangelov, M.. Evaluation of the anticonvulsant effect of novel melatonin derivatives in the intravenous pentylenetetrazol seizure test in mice. European Journal of Pharmacology, 863, 172684, Elsevier, 2019, DOI:10.1016/j.ejphar.2019.172684

Angelova V. T., Rangelov M., Todorova N., Dangalov M., Andreeva-Gateva P., Kondeva-Burdina M., Karabeliov V., Shivachev B., Tchekalarova J.. Discovery of novel indole-based aroylhydrazones as anticonvulsants: Pharmacophore-based design. Bioorganic Chemistry, Elsevier, 2019, DOI:

Gateva, S., Stankov, A., Angelova, T., Todorova, N., Rangelov, M., Zlateva, B., Jovtchev, G.. Evaluation of toxic and genotoxic effects of roundup after direct and indirect treatment. International journal of ecosystems and ecology science (IJEES), 9, 3, 2019, ISSN:2224-4980, DOI:, 409-416


Ecosystem Research, Environmental Risk Assessment and Conservation Biology
Biomonitoring and Ecological Risk Assessment


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9 години 16 седмици